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RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.

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RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.

by
Bednarski, Jeffrey J.; Nickless, Andrew; Bhattacharya, Deepta; Amin, Rupesh H.; Schlissel, Mark S.; Sleckman, Barry P.

Publication date
Collection
pubmed; journals
Contributor
The Rockefeller University Press
Language
English
Volume
209
This article is from The Journal of Experimental Medicine, volume 209.

Abstract

During IgL chain rearrangement in mouse pre–B cells, DNA breaks inflicted by RAG proteins induce Pim2 to promote cell survival and limit proliferation; thus, DNA breaks effectively stand in for the prosurvival cytokine IL-7, whose signaling is attenuated during this stage of B cell development.
Addeddate
2014-10-26 14:58:57
External-identifier
pii:20112078
doi:10.1084/jem.20112078
Identifier
pubmed-PMC3260864
Identifier-ark
ark:/13960/t2c857600
Issn
0022-1007 (Print) 1540-9538 (Electronic)
Journaltitle
The Journal of Experimental Medicine
Ocr
ABBYY FineReader 9.0
Ppi
300
Scanner
Internet Archive Python library 0.7.5
Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260864

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